The Koksu River valley is located in the Pamir‐Alay mountain range and contains 25 glaciers larger than 1 km 2 and numerous smaller glaciers. The largest glacier in the catchment is Abramov Glacier with a current surface area of 22.55 km 2 (in 2022), which was extensively monitored between 1965 and 1999, and resumed in 2011. The long and detailed mass balance time series provide, among other information, benchmark climate variables for the Pamir‐Alay range. We report 10 new cosmogenic 10 Be exposure dates of glacial moraines directly deposited by Abramov Glacier to extend the glacial history of the valley. Six boulders indicate that the Local Last Glacial Maximum occurred at 17.1±1.0 ka. Four boulders suggest a Little Ice Age (LIA) glacial advance around AD 1750. Secular glacier mass balance reconstructions suggest a progressively negative mass balance since the LIA advance. The decrease in mass balance accelerated in the last quarter of the 20th century. Results from repeated ground penetrating radar (GPR) measurements suggest that Abramov Glacier lost about 403 million m 3 of ice volume between 1986 and 2018. Based on the reconstruction of the glacier surface, the corresponding equilibrium line altitude, which is closely correlated with the mass balance, increased by about 70 to 80 m during this period. Our results also suggest that Abramov Glacier has become increasingly out of equilibrium with the climate over the last two decades. This is supported by repeated GPR measurements of the tongue area, which indicate a dramatic decrease in glacier area and ice volume over the period 1986–2018.